$ cat fda_drug_shortages.md
# FDA Drug Shortages & Alternatives
Active-ingredient monitoring registry tracking FDA drug shortage statuses, package NDCs, and clinician-guided therapeutic alternatives.
Active ShortageResolved StatusFDA Source Documented
$ grep "shortage:semaglutide-injection"Currently in Shortage
Semaglutide (Ozempic, Wegovy, Rybelsus)
Shortage Reason: Demand increase for weight management and metabolic health indications
🩺 Clinician-Guided Therapeutic Alternatives:
- Tirzepatide (Mounjaro, Zepbound) under clinician supervision
- Liraglutide (Saxenda, Victoza) subject to local stock
- Rybelsus (oral semaglutide) as an oral comparator alternative
📦 Indexed Drug Packages (5):
$ grep "shortage:tirzepatide-injection"Currently in Shortage
Tirzepatide (Mounjaro, Zepbound)
Shortage Reason: Unprecedented global demand for metabolic and weight-loss indications
🩺 Clinician-Guided Therapeutic Alternatives:
- Semaglutide (Ozempic, Wegovy) subject to local stock
- Liraglutide (Victoza, Saxenda)
- Compounded formulations under strict medical supervision and sourcing validation
📦 Indexed Drug Packages (4):
$ grep "shortage:dextroamphetamine-amphetamine-salts"Currently in Shortage
Amphetamine / Dextroamphetamine (Adderall, Adderall XR)
Shortage Reason: Active pharmaceutical ingredient (API) supply chain constraints and elevated demand
🩺 Clinician-Guided Therapeutic Alternatives:
- Lisdexamfetamine (Vyvanse) generic capsules or chewables
- Methylphenidate ER (Concerta, Ritalin LA) non-amphetamine stimulant alternative
- Non-stimulant alternatives like Atomoxetine (Strattera) or Guanfacine ER (Intuniv)
📦 Indexed Drug Packages (5):
Adderall - Package ReferenceDextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate - Package ReferenceDextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate - Package ReferenceDextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate And Ampheta - Package ReferenceDextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate - Package Reference
$ grep "shortage:lisdexamfetamine-dimesylate"Currently in Shortage
Lisdexamfetamine Dimesylate (Vyvanse)
Shortage Reason: Manufacturing delays post-generic authorization and elevated demand transfer from Adderall shortages
🩺 Clinician-Guided Therapeutic Alternatives:
- Generic Amphetamine Salts IR/XR (Adderall)
- Methylphenidate ER formulations
- Atomoxetine (Strattera) for non-stimulant management
📦 Indexed Drug Packages (5):
$ grep "shortage:albuterol-sulfate-inhalation"Resolved / Intermittent Shortages
Albuterol Sulfate (ProAir HFA, Ventolin HFA, Proventil HFA)
Shortage Reason: Closure of major manufacturing facility producing liquid albuterol solution
🩺 Clinician-Guided Therapeutic Alternatives:
- Levalbuterol (Xopenex HFA) rescue inhaler or solution
- Dry powder inhalers (DPIs) like ProAir RespiClick
- Maintenance corticosteroid inhalers to reduce rescue reliance under clinical direction