mimoleculeindex.com

US vs Canada — Price Gap Watch

Source-backed price comparisons for 25 drugs with both US and Canadian data. Exchange rate ~0.73 USD/CAD used for ratio calculation only.

US pays moreCanada pays more~parity
drugUS best priceCanada best priceratio (US÷CA)
01FarxigaDapagliflozin
$288
30 tablets
GoodRx
$15.66
30 tablets
Ontario Drug Benefit
25.2×
02EnbrelEtanercept
$3,300
4 × 50mg/mL units (1-month supply)
GoodRx
$238
1 dose (50mg/mL)
Ontario Drug Benefit
19.0×
03HydrochlorothiazideHydrochlorothiazide
$4
30 tablets
GoodRx
$0.47
30 tablets
Ontario Drug Benefit
11.7×
04MetforminMetformin Hydrochloride
$5.32
30 tablets
Cost Plus Drugs
$0.74
30 tablets
Ontario Drug Benefit
9.8×
05SynthroidLevothyroxine Sodium
$6.25
30 tablets
Cost Plus Drugs
$1.38
30 tablets
Ontario Drug Benefit
6.2×
06JardianceEmpagliflozin
$352
30 tablets
GoodRx
$86.60
30 tablets
Ontario Drug Benefit
5.6×
07CrestorRosuvastatin Calcium
$6.82
30 tablets
Cost Plus Drugs
$4.06
30 tablets
Ontario Drug Benefit
2.3×
08LyricaPregabalin
$13.60
60 capsules (2-month supply)
GoodRx
$9
30 capsules
Ontario Drug Benefit
2.1×
09GabapentinGabapentin
$11
90 capsules
GoodRx
$9
90 capsules
Ontario Drug Benefit
1.7×
10HumiraAdalimumab
$550
2-pen carton (1-month supply)
GoodRx / Boehringer Ingelheim biosimilar program
$471.27
1 prefilled pen (40mg/0.4mL)
Ontario Drug Benefit
1.6×
11AmlodipineAmlodipine Besylate
$5.20
30 tablets
Cost Plus Drugs
$4.50
30 tablets
Ontario Drug Benefit
1.6×
12LisinoprilLisinopril
$5.39
30 tablets
Cost Plus Drugs
$4.86
30 tablets
Ontario Drug Benefit
1.5×
13PrilosecOmeprazole
$5.93
30 capsules
Cost Plus Drugs
$6.86
30 capsules
Ontario Drug Benefit
1.2×
14LipitorAtorvastatin Calcium
$5.74
30 tablets
Cost Plus Drugs
$7.03
30 tablets
Ontario Drug Benefit
≈ parity
15ClarithromycinClarithromycin
$31.10
60 tablets
Cost Plus Drugs
$38.80
30 tablets
Ontario Drug Benefit
≈ parity
16XareltoRivaroxaban
$16.51
30 tablets
Cost Plus Drugs
$21.53
30 tablets
Ontario Drug Benefit
≈ parity
17WellbutrinBupropion Hydrochloride
$5.99
30 tablets
Cost Plus Drugs
$8.78
30 tablets
Ontario Drug Benefit
≈ parity
18LexaproEscitalopram Oxalate
$6.32
30 tablets
Cost Plus Drugs
$9.33
30 tablets
Ontario Drug Benefit
≈ parity
19ZoloftSertraline Hydrochloride
$6.04
30 tablets
Cost Plus Drugs
$9.91
30 tablets
Ontario Drug Benefit
1.2× CA
20LosartanLosartan Potassium
$5.51
30 tablets
Cost Plus Drugs
$9.44
30 tablets
Ontario Drug Benefit
1.3× CA
21LantusInsulin Glargine
$35
30-day supply
Sanofi Valyou Savings Program
$61.69
10mL vial (100U/mL)
Ontario Drug Benefit
1.3× CA
22ProzacFluoxetine Hydrochloride
$5.44
30 capsules
Cost Plus Drugs
$9.90
30 capsules
Ontario Drug Benefit
1.3× CA
23StelaraUstekinumab
$2,181.91
26 mL supply
Drugs.com price guide
$4,593.15
single-use prefilled syringe
NCBI/CADTH public cost table
1.5× CA
24CymbaltaDuloxetine Hydrochloride
$6.47
30 capsules
Cost Plus Drugs
$29.40
30 capsules
Ontario Drug Benefit
3.3× CA
25NexiumEsomeprazole Magnesium
$5.90
30 capsules
Cost Plus Drugs
$56.07
30 capsules
Ontario Drug Benefit
6.9× CA

Notable findings

13
drugs where US pays significantly more
7
drugs where Canada pays more (rare inversions)
5
drugs at approximate price parity
⚠ Rare inversions Zoloft, Losartan, Lantus, Prozac, Stelara, Cymbalta, Nexium — Canada pays more than the US. Usually explains biosimilar mandate delays or limited formulary competition.